Zonulin is a protein secreted by intestinal cells that regulates intercellular tight junctions. Zonulin regulates barrier permeability. Serum zonulin correlates with intestinal permeability and lactulose/mannitol tests for intestinal permeability. High serum zonulin has been associated with celiac disease, type 1 diabetes, insulin resistance and type 2 diabetes, cancers, neurological conditions, and autoimmune diseases. The level of the zonulin antigen in stool may provide a noninvasive indication of intestinal permeability (“leaky gut”). 

Performing Lab: DSL