Fibrinogen or Factor I is an acute phase inflammatory plasma protein synthesized by the liver and is an essential component in the clotting cascade.
Methodology
Immunoturbidimetric
- Fibrinogen is converted by thrombin to form fibrin, which is crosslinked with another protein in the final step in the formation of a blood clot.
- Elevated levels are associated with inflammation.
- Every 100 mg/dL increase in plasma fibrinogen level > 370 mg/dL has been associated with a 1.8 fold increased risk of CVD.1
References:
- Fibrinogen Studies Collaboration. Danesh J, Lewington S, Thompson SG, et al. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA. 2005;294(14):1799-1809.
