Thyroid Stimulating Hormone (TSH) (1005)

TSH is a peptide hormone synthesized and secreted by the anterior pituitary gland. TSH regulates thyroid gland function.

Methodology

Immunoassay

• TSH is used in the differential diagnosis of primary, secondary, & tertiary hypothyroidism.1-3
• Is also useful in screening for hyperthyroidism.1-3
• Allows adjustment of thyroid replacement in hypothyroid patients.1-3
• High doses of biotin (> 5 mg/day) may interfere with assay results. Patient assumed to be refraining from biotin supplementation for at least 3 days prior to blood draw.

References:

1. Goodman N, Cobin RH. Reproductive disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:190-228.
2. Castro MR, Gharib H. Thyroid disorders. In: Camacho PM, Gharib H, Sizemore GW, eds. Evidence-Based Endocrinology. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins. 2012:43-80.
3. Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):988-1028.